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Diffuse parenchymal lung disease

**{{{Name|Diffuse parenchymal lung disease}}}**
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, J701, J841, P278|

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 eMedicineSubj  = ped |
 eMedicineTopic = 1950 |
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}} Diffuse parenchymallung disease (DPLD), also known as interstitial lung disease, refers to a group of lungdiseases, affecting the alveolarepithelium, pulmonary capillaryendothelium, basement membrane, perivascular and perilymphatic tissues. The term DPLD is used to distinguish these diseases from obstructive airways diseases. Most types of DPLD involve fibrosis, but this is not essential; indeed fibrosis is often a later feature. Hence the term pulmonary fibrosis has fallen out of favor.

Inhaltsverzeichnis

1 Causes
2 Investigation
3 Treatment
4 External links

Causes

DPLD may be classified according to the cause: -

Inhaled substances
- Inorganic
  - Silica
  - Asbestos
  - Beryllium
- Organic
  - Hypersensitivity pneumonitis
Druginduced
- Antibiotics
- Chemotherapeutic drugs
- Antiarrhythmicdrugs
Connective tissue disease
- Systemic sclerosis
- Dermatomyositis
- Systemic lupus erythematosus
- Rheumatoid arthritis
Infection
- Atypical pneumonia
- Pneumocystis carinii pneumonia
- Tuberculosis
Idiopathic
- Sarcoidosis
- Idiopathic pulmonary fibrosis
- Hamman-Rich syndrome
Malignancy
- Lymphangitic carcinomatosis

Investigation

Investigation is tailored towards the symptoms and signs. Most patients have blood testing, chest x-ray, pulmonary function testing, and high resolution CTthorax.

Treatment

DPLD is not a single disease, but encompasses many different pathological processes. Hence treatment is different for each disease.

If a specific occupational exposure cause is found, the person should avoid that environment. If a drug cause is suspected, that drug should be discontinued.

Many idiopathic and connective tissue-based causes of DPLD are treated with prednisolone. Some patients respond to immunosuppressanttreatment. Patients with hypoxemiamay be given supplemental oxygen.

External links

What is Pulmonary Fibrosis?
Chorus00736
GPnotebook1476788304
MeSHPulmonary+Fibrosis
MedlinePlus Overviewpulmonaryfibrosis

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