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Wernicke-Korsakoff syndrome

**{{{Name|Wernicke-Korsakoff syndrome}}}**
[[Image:{{{Image}}}\|190px\|center\|]] {{{Caption\|}}}
ICD-10	E51.2, F10.6
ICD-O:	{{{ICDO}}}
ICD-9	294.0
OMIM	}}}
MedlinePlus	}}}
eMedicine	}}}
DiseasesDB	}}}

Wernicke-Korsakoff syndrome is a combination of Korsakoff's syndrome, which is characterized by confusion, severe anterogradeand retrograde amnesiaand confabulation; and Wernicke's encephalopathy, which is characterized by nystagmus, ophthalmoplegia, comaand, if untreated, death.

Inhaltsverzeichnis

1 Causes
2 Diagnosis
3 Treatment
4 External link

Causes

Wernicke-Korsakoff syndrome results from severe acute deficiencyof thiamine superimposed on a chronic deficiency. Thiamine is a cofactorin glucose metabolism, and so anything that encourages glucose metabolism without replenishing stores of thiamine may result in Wernicke-Korsakoff syndrome, which is usually found in malnourished chronic alcoholics, though it is also found in patients who undergo prolonged intravenous(IV) therapy, gastric staplingor intensive care unit(ICU) stays. The site of damage in the brain is the mammillary bodies.

Some studies have associated susceptiblity to this syndrome with a hereditary deficiency of transketolase, an enzyme involved in thiamine metabolism.

Diagnosis

Diagnosisis by clinical impression, but can be confirmed by measuring blood levelsof thiamine.

Treatment

Treatment consists of reversing the thiamine deficiency by giving supplemental thiamine, usually by starting with an initial intravenous or intramuscular dose followed by supplemental oral doses. By the time amnesiaand psychosishave occurred, complete recovery is unlikely.

External link

Wernicke-Korsakoff syndromede:Wernicke-Korsakow-Syndrom

fr:Syndrome de Wernicke-Korsakoff is:Wernicke-Korsakoff heilkenni nl:Syndroom van Wernicke pt:Wernicke-Korsakov

This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Wernicke-Korsakoff+syndrome Wikipedia article Wernicke-Korsakoff syndrome.

All text is available under the terms of the GNU Free Documentation License