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Yolk sac tumour

**{{{Name|Yolk sac tumour}}}**
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ICD-10	(ICD-O9071/3)
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ICD-9
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Yolk sac tumours are members of the germ cell tumourgroup of ovarian neoplasms. Almost all ovarianyolk sactumoursoccur in womenunder the age of 30. Patients usually present with sudden onset painand a large pelvic mass. Serum alpha-fetoprotein(AFP) is elevated in virtually all cases and is the prototypic serum marker for ovarian tumours in young patients. At laparotomy, there is spread to the peritoneumor lymph nodesin 30-70% of cases.

The tumours are soft and friable with a smooth external surface and a cystic and perhaps solid variegated yellow or gray sectioned surface. Extensive hemorrhageand necrosisis usual.

Microscopically, there is a wide variety of patterns and several histologic subtypes. Typical features are Schiller-Duval bodiesand eosinophilichyalineglobules. Before contemporary chemotherapy, this type of neoplasm was highly lethal, but the prognosis has significantly improved since.

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