Genotoxic

Genotoxic substances are those chemical compoundscapable of causing geneticmutationand of contributing to the developmentof tumors. Radiationis also considered to be genotoxic.

Typical genotoxins like aromatic aminesare believed to cause mutations because they are electrophilicand form strong covalent bondswith DNA, preventing accurate replication.

References

• Environ Health Perspect 104(Suppl 6):1219-1225 (1996)- The Mechanism of Benzene-induced Leukemia: A Hypothesis and Speculations on the Causes of Leukemianl:Genotoxisch

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