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Fibrosarcoma
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Fibrosarcoma (fibroblastic sarcoma) is a malignanttumorderived from fibrous connective tissue and characterized by immature proliferatingfibroblastsor undifferentiated anaplasticspindle cells.
Inhaltsverzeichnis
- 1 Pathology
- 2 Fibrosarcoma in dogs and cats
- 3 See also
- 4 External links
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Pathology
The tumor may present different degrees of differentiation: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumor cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone". Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing.
Fibrosarcoma in dogs and cats
Fibrosarcoma occurs most frequently in the the mouth in dogs. The tumor is locally invasive, and reoccurs often following surgery. Radiation therapyand chemotherapyare also used in treatment. Fibrosarcoma is also a rare bone tumor in dogs.
In cats, fibrosarcoma occurs on the skin. It also the most common vaccine-associated sarcoma.
Reference
- Ettinger, Stephen J.;Feldman, Edward C.(1995).Textbook of Veterinary Internal Medicine(4th ed.). W.B. Saunders Company. ISBN 0-7216-6795-3
See also
- Fibrous connective tissue
- Fibroma
External links
| Tumors (and related structures), Cancer, and Oncology
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| Benign- Premalignant- Carcinoma in situ- Malignant
Topography: Anus- Bladder- Bone- Brain- Breast- Cervix- Colon/rectum- Duodenum- Endometrium- Esophagus- Eye- Gallbladder- Head/Neck- Liver- Larynx- Lung- Mouth- Pancreas- Penis- Prostate- Kidney- Ovaries- Skin- Stomach- Testicles- Thyroid
Morphology: Papilloma/carcinoma- Adenoma/adenocarcinoma- Soft tissue sarcoma- Melanoma- Fibroma/fibrosarcoma - Lipoma/liposarcoma- Leiomyoma/leiomyosarcoma- Rhabdomyoma/rhabdomyosarcoma- Mesothelioma- Angioma/angiosarcoma- Osteoma/osteosarcoma- Chondroma/chondrosarcoma- Glioma- Lymphoma/leukemia
Treatment: Chemotherapy- Radiation therapy- Immunotherapy- Experimental cancer treatment
Related structures: Cyst- Dysplasia- Hamartoma- Neoplasia- Nodule- Polyp- Pseudocyst
Misc: Tumor suppressor genes/oncogenes- Staging/grading- Carcinogenesis/metastasis- Carcinogen- Research- Paraneoplastic phenomenon- ICD-O- List of oncology-related terms
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Categories: Oncology| Dog health| Cat health
This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Fibrosarcoma Wikipedia article Fibrosarcoma.
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