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Tissue plasminogen activator

In blood coagulation, tissue plasminogen activator (tPA) is an enzyme(EC3.4.21.68) that activates plasminogen, leading to fibrinolysis.

RecombinanttPA is used in diseases which feature blood clots, such as myocardial infarctionand stroke. To be effective, tPA must be administered within the first six or so hours of the attack. Because of this, only about 3% of patients qualify for this treatment. Since tPA dissolves blood clots, there is risk of hemorrhagewith its use.

See also

  • Thrombolysis

External links

  • http://www.americanheart.org/presenter.jhtml?identifier=4751
  • http://www.guideline.gov/summary/summary.aspx?doc_id=3422
Image:AlphaHelixSection.png This biochemistryarticle is a stub. You can helpWikipedia by expanding it.


Coagulation
Coagulation factors: - Fibrin(I) - (Pro)thrombin(II) - FV- FVII- FVIII- FIX- FX- FXI- FXII- FXIII- HMWK- vWF- Thromboplastin
Inhibitors: Antithrombin- Protein C- Protein S- Protein Z- ZPI- TFPI
Fibrinolysis: Plasmin- tPA/urokinase- PAI-1/2- α2-AP- TAFI
Retrieved from "http://en.wikipedia.org/Tissue_plasminogen_activator"



This article is licensed under the GNU Free Documentation License.
It uses material from the http://en.wikipedia.org/wiki/Tissue+plasminogen+activator Wikipedia article Tissue plasminogen activator.

 
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