β-lactam antibiotics are a broad class of antibioticsincluding penicillin derivatives, cephalosporins, monobactams, carbapenemsand β-lactamase inhibitors; basically any antibiotic agent which contains a β-lactamnucleus in its molecular structure. They are the most widely used group of antibiotics available.
- 1 Clinical use
- 2 Mode of action
- 3 Modes of resistance
- 4 Common β-lactam antibiotics
- 4.1 Penicillins
- 4.1.1 Narrow spectrum penicillins
- 4.1.2 Narrow spectrum penicillinase-resistant penicillins
- 4.1.3 Moderate spectrum penicillins
- 4.1.4 Broad spectrum penicillins
- 4.1.5 Extended Spectrum Penicillins
- 4.2 Cephalosporins
- 4.2.1 First generation cephalosporins
- 4.2.2 Second generation cephalosporins
- 4.2.3 Second generation cephamycins
- 4.2.4 Third generation cephalosporins
- 4.2.5 Fourth generation cephalosporins
- 4.3 Carbapenems
- 4.4 Monobactams
- 4.5 Beta-lactamase inhibitors
- 5 Adverse effects
- 5.1 Adverse drug reactions
- 5.2 Allergy/hypersensitivity
- 6 References
β-lactam antibiotics are indicated for the prophylaxisand treatment of bacterialinfections caused by susceptible organisms. Whilst, traditionally, β-lactam antibiotics were mainly active only against Gram-positivebacteria, the development of broad-spectrum β-lactam antibiotics active against various Gram-negativeorganisms has increased the usefulness of the β-lactam antibiotics.
Mode of action
β-Lactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycanlayer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positiveorganisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidasesknown as penicillin binding proteins(PBPs).
β-lactam antibiotics are analogues of D-alanyl-D-alanine - the terminal amino acidresidues on the precursor NAM/NAG-peptide subunits of the nascent peptidoglycan layer. The structural similarity between β-lactam antibiotics and D-alanyl-D-alanine facilitates their binding to the active site of penicillin binding proteins(PBPs). The β-lactam nucleus of the molecule irreversibly binds to (acylates) the Ser403 residue of the PBP active site. This irreversible inhibition of the PBPs prevents the final crosslinking (transpeptidation) of the nascent peptidoglycan layer, disrupting cell wall synthesis. Inhibition of PBPs may also lead to the activation of autolytic enzymes in the bacterial cell wall.
Modes of resistance
By definition, all β-lactam antibiotics have a β-lactam ring in their structure. The effectiveness of these antibiotics relies on their ability to reach the PBP intact and their ability to bind to the PBP. Hence, there are 2 main modes of bacterial resistance to β-lactams, as discussed below.
The first mode of β-lactam resistance is due to enzymatic hydrolysisof the β-lactam ring. If the bacteria produces the enzymesβ-lactamaseor penicillinase, these enzymes will break open the β-lactam ring of the antibiotic, rendering the antibiotic ineffective. The genes encoding these enzymes may be inherently present on the bacterial chromosomeor may be acquired via plasmidtransfer, and beta-lactamase gene expressionmay be induced by exposure to beta-lactams. The production of a β-lactamase by a bacterium does not necessarily rule out all treatment options with β-lactam antibiotics. In some instances, β-lactam antibiotics may be co-administered with a β-lactamase inhibitor.
However, in all cases where infection with β-lactamase-producing bacteria is suspected, the choice of a suitable β-lactam antibiotic should be carefully considered prior to treatment. In particular, choosing appropriate β-lactam antibiotic therapy is highly important against organisms with inducible β-lactamase expression. If β-lactamase production is inducible, then failure to use the most appropriate β-lactam antibiotic therapy at the onset of treatment will result in induction of β-lactamase production, thereby making further efforts with other β-lactam antibiotics more difficult.
The second mode of β-lactam resistance is due to possession of altered penicillin binding proteins. β-lactams cannot bind as effectively to these altered PBPs, and as a result, the β-lactams are less effective at disrupting cell wall synthesis. Notable examples of this mode of resistance include methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae. Altered PBPs do not necessarily rule out all treatment options with β-lactam antibiotics.
Common β-lactam antibiotics
Main article: penicillin
Narrow spectrum penicillins
- benzathine penicillin
- benzylpenicillin(penicillin G)
- phenoxymethylpenicillin(penicillin V)
- procaine penicillin
Narrow spectrum penicillinase-resistant penicillins
Moderate spectrum penicillins
Broad spectrum penicillins
- co-amoxiclav (amoxycillin+clavulanic acid)
Extended Spectrum Penicillins
Main article: cephalosporin
First generation cephalosporins
Second generation cephalosporins
Moderate spectrum with anti-Haemophilus activity.
Second generation cephamycins
Moderate spectrum with anti-anaerobic activity.
Third generation cephalosporins
Broad spectrum with anti-Pseudomonas activity.
Fourth generation cephalosporins
Broad spectrum with enhanced activity against Gram positive bacteriaand beta-lactamasestability.
Main article: carbapenem
Broadest spectrum of beta-lactam antibiotics.
- imipenem(with cilastatin)
Unlike other beta-lactams, there is no fused ring attached to beta-lactam nucleus. Thus, there is less probability of cross-sensitivity reactions.
No antimicrobial activity. Their sole purpose is to prevent the inactivation of beta-lactam antibiotics by beta-lactamases, and as such, they are co-administered with beta-lactam antibiotics.
- clavulanic acid
Adverse drug reactions
Common adverse drug reactions (ADRs) for the β-lactam antibiotics include: diarrhoea, nausea, rash, urticaria, superinfection (including candidiasis). (Rossi, 2004)
Infrequent ADRs include: fever, vomiting, erythema, dermatitis, angioedema, pseudomembranous colitis. (Rossi, 2004)
Pain and inflammation at the injection site is also common for parenterally-administered β-lactam antibiotics.
Allergicreactions to any β-lactam antibiotic may occur in up to 10% of patients receiving that agent. Anaphylaxiswill occur in approximately 0.01% of patients. (Rossi, 2004) There is perhaps a 5-10% cross-sensitivity between penicillin-derivatives, cephalosporins and carbapenems; but this figure has been challenged by various investigators.
Nevertheless, the risk of cross-reactivity is sufficient to warrant the contraindication of all β-lactam antibiotics in patients with a history of severe allergic reactions (urticaria, anaphylaxis, interstitial nephritis) to any β-lactam antibiotic.
- Rossi S (Ed.) (2004). Australian Medicines Handbook2004. Adelaide: Australian Medicines Handbook. ISBN 0-9578521-4-2.de:?-Lactam-Antibiotika
es:Los antibiótico del beta-lactam
Categories: Beta-lactam antibiotics
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It uses material from the http://en.wikipedia.org/wiki/Beta-lactam+antibiotics Wikipedia article Beta-lactam antibiotics.