Homology (biology)

In biology, two or more structures are said to be homologous if they are alike because of shared ancestry. This could be evolutionaryancestry, meaning that the structures evolved from some structure in a common ancestor (the wings of batsand the arms of humansare homologous in this sense), or developmental ancestry, meaning that the structures arose from the same tissue in embryonaldevelopment (the ovariesof female humans and the testiclesof male humans are homologous in this sense).

Homology has to be distinguished from analogy; for instance, the wings of insects, the wings of batsand the wings of birdsare analogous but not homologous, this phenomena is known as Homoplasy. These similar structures evolved through different developmentalpathways, in a process known as convergent evolution.

Homology of sequences in genetics

In genetics, homology is used in reference to proteinor DNAsequences, meaning that the given sequences share a common ancestor. Sequence homology may also indicate common function. Homology is an all-or-nothing quality; there is no such condition as "degrees of homology." Sequence regions that are homologous may be called conserved, consensus or canonical sequences and represent the most common choice of base or amino acid at each position.

Homology among proteins and DNA is often concluded on the basis of sequence similarity, especially in bioinformatics. For example, in general, if two genes have an almost identical DNA sequence, it is likely that they are homologous. However, it may be that the sequence similarity did not arise from their sharing a common ancestor; short sequences may be similar by chance, or sequences may be similar because both were selected to bind to a particular protein, such as a transcriptionfactor. Such sequences are similar but not homologous. Many algorithms exist to cluster protein sequences into sequence families, which are sets of mutually homologous sequences. (See sequence clusteringand sequence alignment.)

Orthology and paralogy

Homology of sequences can be of two types: orthology or paralogy. Homologous sequences are orthologous if they were separated by a speciationevent: if a gene exists in a species, and that species diverges into two species, then the copies of this gene in the resulting species are orthologous. Homologous sequences are paralogous if they were separated by a gene duplicationevent: if a gene in an organism is duplicated, then the two copies are paralogous. A pair of sequences that are orthologous to each other are called orthologs ( see Orthologue), a pair that are paralogous are called paralogs.

Orthologs will typically have the same or similar function. This is not always true for paralogs: due to lack of the original selective pressure upon one copy of the duplicated gene, this copy is free to mutate and acquire new functions.

The genes encodingmyoglobinand hemoglobinare considered to be ancient paralogs. Similiarly, the four known classes of hemoglobins (hemoglobin A, hemoglobin A2, hemoglobin S, and hemoglobin F) are all paralogs of each other. While each of these genes serve the same basic function of oxygen transport, they have already diverged slightly in function: fetal hemoglobin (hemoglobin F) has a higher affinity to oxygen than adult hemoglobin.

Another example can be found in rodents such as rats and mice. Rodents have a pair of paralogous insulingenes, although it is unclear if any divergence in function has occurred.

Paralogous genes often belong to the same species, but this is not necessary: for example, the hemoglobin gene of humans and the myoglobin gene of chimpanzees are paralogs. This is a common problem in bioinformatics: when the genome of different species have been sequenced and homologous genes have been found, one can not immediately conclude that these genes have the same or similar function, as they could be paralogs whose function has diverged.

Homologous chromosome pairs

A homologous pair of chromosomesin a diploidcellis a matching pair of chromosomes, one derived from each parent of the organism. Except for the sex chromosomes, the chromosomes of each homologous pair share significant sequence similarity across their entire length, and thus typically contain the same sequence of genes. The sex chromosomes have a shorter region of sequence similarity. Based on the sequence similarity and our knowledge of biology, we can presume that the chromosomes are paralogous.

See also

• Cladistics
• List of Homologues of the Reproductive System
• Serial homology
• Sexual homology

de:Homologie (Biologie) ja:相同性 (生物学) tr:homolog organ

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It uses material from the http://en.wikipedia.org/wiki/Homology+%28biology%29 Wikipedia article Homology (biology).