T-Lymphocytopenia

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Idiopathic CD4+ lymphocytopenia (ICL) is a depletion of CD4+ lymphocytes below 300 per cubic millimeter, or less than 20% of total lymphocytes, in the absence of HIV infection or other known causes of immunodeficiency. This is a rare, heterogeneous syndrome and does not appear to be caused by a transmissible agent.Online Medical Dictionary entry on T-lymphocytopenia People with ICL are susceptible to opportunistic infections, namely, cryptococcus, atypical mycobacterial and Pneumocystis jiroveci pneumonia (PCP).Criteria for diagnosis of idiopathic CD4 lymphocytopenia include:UpToDate article on "Techniques and interpretation of measurement of the CD4 cell count in HIV-infected patients", by John G. Bartlett. Accessed 30 Oct 2006.
  • CD4 cell count less than 300/mm3 or a CD4 percent less than 20 of total lymphocytes on two or more measurements
  • Lack of laboratory evidence of HIV infection
  • Absence of an alternative explanation for the CD4 lymphocytopenia
    • ICL is a rare disease; in 1993, a total of 47 confirmed cases were reported in a survey sponsored by the Centers for Disease Control. In contrast to the CD4 cell depletion caused by HIV, patients with idiopathic CD4 lymphocytopenia generally have a good prognosis.

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