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Myokmia is an involuntary and continuous Myoclonus (muscle twitch) that affects the muscles of the face, particularly the eyelids, as a result of the random firing of neurons leading into the muscle fibres. It is mainly caused by a lack of sleep, or increased intake of nicotine, caffeine, or by stress. However, Myokmia can also or rare occasions be a pathognomonic symptom of lesions on the brain stem, multiple sclerosis or pontine glioma.Sharma RR, Mathad NV, Joshi DN, Mazarelo TB, Vaidya MM. Persistent facial myokymia: A rare pathognomic physical sign of intrinsic brain-stem lesions: report of 2 cases and review of literature However, these causes are extremely rare, with only 2 out of 132 cases of Myokmia diagnosed at Seth G.s. Medical College in Bombay being caused by such lesions.Tharakan J, Bhatia R. Continuous hemiacial spasm in cerebello-pontine angle tumours Neurol India 1981
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