From Wikipedia, the free encyclopedia
A metabolic disorder
is a medical disorder which affects the production of energy within individual animal cells. Most metabolic disorders
are genetic, though a few are "acquired" as a result of diet, toxins, infections, etc. Genetic metabolic disorders are also known as inborn errors of metabolism.In general, the genetic metabolic disorders
are caused by genetic defects that result in missing or improperly constructed enzymes necessary for some step in the metabolic process of the cell.The largest classes of metabolic disorders
are: Disorders of carbohydrate metabolism
Disorders of amino acid metabolism
Disorders of organic acid metabolism (organic acidurias)
Disorders of fatty acid oxidation and mitochondrial metabolism
Disorders of porphyrin metabolism
Disorders of purine or pyrimidine metabolism
Disorders of steroid metabolism
Disorders of mitochondrial function
Disorders of peroxisomal function
Lysosomal storage disorders(for further details, see inborn errors of metabolism)
A fourth class, the channelopathies (some of which cause periodic paralysis and/or malignant hyperthermia) could be considered to be metabolic disorders
as well, though they are not always classified as such. These disorders affect the ion channels in the cell and organelle membranes, resulting in improper or inefficient transfer of ions through the membranes.There are also a number of other metabolic disorders
(such as myoadenylate deaminase deficiency) which do not cleanly fit into any of the above classifications.
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