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Leaky gut syndrome is a diagnostic entity prevalent in various branches of alternative medicine. Its proponents hypothesize that damage to the bowel lining, caused by antibiotics, toxins, poor diet, parasites or infection (e.g. with the yeast Candida albicans) ZP Rona,Altered Immunity & Leaky Gut Syndrome can lead to increased permeability of the gut wall to toxins, microbes, undigested food, waste or larger than normal macromolecules.S. Martin, Intestinal Permeability, BioMed Newsletter Issue No. 11, May 1995. Some versions posit that these substances affect the body directly, while others postulate an immune reaction to these substances.Kiefer D, Ali-Akbarian L. A brief evidence-based review of two gastrointestinal illnesses: irritable bowel and leaky gut syndromes. Altern Ther Health Med 2004;10:22-30. PMID 15154150. While many practitioners maintain that leaky gut syndrome is a bona fide medical condition, the area of "gut problems" lies between conventional and alternative medicine, including other diagnostic titles such as Small bowel bacterial overgrowth syndrome or small intestine bacterial overgrowth (SIBO), and "yeast syndrome" or systemic candidiasis, remains controversial and scientifically unsettled.Pizzorno, JE, Murray, MT, (November 2005) Textbook of Natural Medicine, 3rd edition, Churchill Livingstone, pp 167, 584, 1527 ISBN 0-443-07300-7The concept of increased gut permeability itself is well recognised in various conditions, such as hepatic encephalopathy. It has been discovered that Zonulin regulates intestinal permeability.Dr. Alessio Fasano is currently partnered with http://www.albatherapeutics.com/ in the development of the drug AT-1001 that regulates permeability. The drug is being fast-tracked and trials are currently underway. Fasano's research has found that intestinal permeability and overproduction of zonulin is present in almost all autoimmune diseases. Although experts differ on the causes of leaky gut (candida, antibiotics, bacterial infections, chemotherapy, poor diet, gluten grains) leaky gut is no longer considered "alternative medicine".
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