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Dyscrasia, is a concept from ancient Greek medicine with the word "dyskrasia", meaning bad mixture.Aphorism 79 or Organon of Medicine by Dr. Samuel Hahnemann To the Greeks, it meant an imbalance of the four humors: blood, black bile, yellow bile, and water (phlegm). These humors were believed to exist in the body, and were the direct cause of all disease. This is similar to the Asian concept of Yin and Yang that an imbalance of the two polarities caused ailment.It is still occasionally used in medical context for an unspecified disorder of the blood. Specifically it is defined in current medicine as a morbid general state resulting from the presence of abnormal material in the blood, usually applied to diseases affecting blood cells or platelets. Stedman's medical dictionary, 6th edition Antimetabolitic Agents such as Leucovorin, Methotrexate, etc. may cause blood dyscrasias. Spironolactone (Potassium sparing diuretic), when used as a pro-drug to treat Conn's Disease may cause this side effect
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