From Wikipedia, the free encyclopedia
Cortical spreading depression
is an expression used by some neuroscientists to represent at least one of the following cortical processes:
The spreading of a self-propagating wave of cellular depolarization in the cerebral cortex.
The spreading of a wave of ischemia passing through an area of cortex.
The spreading of a wave of vasoconstriction following vasodilation of contiguous cortical arterioles.
["Mechanisms of migraine aura revealed by functional MRI in human visual cortex", Hadjikhani et al., PNAS 98 (2001), pages 4687-4692.]
The scintillating scotoma of migraine in humans may be related to the neurophysiologic phenomenon termed the spreading depression of Leão.
[Leão AAP, "Spreading depression of activity in the cerebral cortex", J Neurophysiol. 7 (1944), pages 359-390.]
The spreading depression wave progresses across the cortex at approximately 3.6 mm/minute.
["Speed of progression of migrainous visual aura measured by sequential field assessment", Porooshani, Porooshani, Gannon, and Kyle, Neuro-Ophthalmology, 28:2 (2004), pages 101-105.]
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