Complement component 4

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Complement component 4 is a protein involved in the complement system. It is cleaved into proteins 4a and 4b.
  • C4a is an anaphylatoxin.
  • C4b forms part of C3-convertase, in conjunction with 2a:
  • C4b can bind CR1.

    • Clinical significance

    It is responsible for the Chido Rodgers blood group system.Chido Rodgers blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIHC4d has been identified as a biomarker for systemic lupus erythematosus.

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