CD44
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, , | Name = CD44 molecule (Indian blood group) | HGNCid = 1681 | Symbol = CD44 | AltSymbols =; CDW44; CSPG8; ECMR-III; HCELL; IN; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH-I; Pgp1 | OMIM = 107269 | ECnumber = | Homologene = 508 | MGIid = 88338 | GeneAtlas_image1 = PBB_GE_CD44_204490_s_at_tn.png | GeneAtlas_image2 = PBB_GE_CD44_212063_at_tn.png | GeneAtlas_image3 = PBB_GE_CD44_204489_s_at_tn.png | Function = | Component = | Process = | Orthologs = The CD44 protein is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs).This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. Gene transcription is at least in part activated by beta catenin and Wnt signalling (also linked to tumour development). The protein is a determinant for the Indian blood group system.
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